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Grignard Reactions: A legacy chemistry, reborn

The Grignard reaction is a method for forming carbon-carbon bonds. Alkyl or aryl magnesium halides are typically reacted with electrophilic carbonyl compounds such as aldehydes, ketones or esters to produce the corresponding alcohols or ketones. Grignard reagent production is also important for a host of chemistries, including the preparation of boron derivatives for Suzuki coupling.  Reagents are typically prepared from alkyl or aryl halides by reaction with metallic magnesium.

Target molecules:

  • Alcohols

Advantage CABB:

Both Jayhawk and Kokkola offer Grignard reagents for commercial sale as well as captive use in Grignard reactions.