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Suzuki Reaction: Ideal for cross-coupling

Suzuki coupling is a widely used cross coupling reaction between an organohalide and an organoborinic acid. The reaction is typically catalyzed by a Pd-based catalyst and runs under mild conditions. A wide variety of solvents can be used, including water, aromatic solvents such as toluene and ethers such as THF. This reaction has found use in both the agrochem and pharmaceutical areas due to its broad capability.

The Suzuki coupling reaction has been well-accepted because the more common organoboronic and borinic acids are commercially available or are relatively inexpensive to produce. In general, the toxicity of the organoboron compounds are lower than other organometallics that might be considered for this chemistry.

Suzuki coupling can be the reaction of choice for production of intermediates and bulk active agrochems, pharmaceuticals and other fine and specialty chemicals.

Target molecules:

  • Substituted biphenyls
  • Dienes

Advantage CABB:

CABB uses Suzuki coupling in the production of our chemical building blocks.  Both the Jayhawk and Kokkola sites are adept at cross-coupling technology.