Lithiation: Low-temperature organometallic chemistry

Lithiation reactions generate highly active nucleophiles by deprotonation or lithium-halogen exchange and the reactive intermediate is often used directly in a reaction with an electrophile. Due to the extremely high reactivity of lithiation reagents such as butyl lithium (BuLi), high selectivity in lithiation reactions typically require low reaction temperature which can be reached with cryogenic cooling media.

Target molecule:

Lithiated intermediates

Advantage CABB:

Commercial lithiation reactions require the right infrastructure. CABB operates a dedicated system from storage tanks for lithium reagents and piping systems to the corresponding unit operations, ensuring process safety and security.